| Sun | Mon | Tue | Wed | Thu | Fri | Sat |
| | | | | | |
| | 3 | away at Texas Rangers 2pm (season opener) WIN 7-3 WP: C.Schilling |
| | 4 | away at Texas Rangers 8pm loss 4-10 |
| | 5 | away at Texas Rangers 8pm WIN 2-1 WP: J.Beckett |
| | | 7 | away at Baltimore Orioles 7pm WIN 14-8 WP: M.Clement |
| | 8 | away at Baltimore Orioles 4pm WIN 2-1 WP: C.Schilling |
|
| 9 | away at Baltimore Orioles 1pm WIN 4-1 WP: T.Wakefield |
| | | 11 | vs. Toronto Blue Jays 2pm (home opener) JON WIN 5-3 WP: J.Beckett |
| | 12 | vs. Toronto Blue Jays 7pm PAUL loss 4-8 |
| | 13 | vs. Toronto Blue Jays 7pm RON loss 6-8 |
| | 14 | vs. Seattle Mariners 7pm ADAM K WIN 2-1 WP: C.Schilling |
| | 15 | vs. Seattle Mariners 1pm JON loss 0-3 |
|
| 16 | vs. Seattle Mariners 2pm RAE WIN 3-2 WP: J.Beckett |
| | 17 | vs. Seattle Mariners 11am (Marathon Monday) JON WIN 7-6 WP: M.Timlin |
| | 18 | vs. Tampa Bay Devil Rays 7pm ALBERT WIN 7-4 WP: M.Timlin |
| | 19 | vs. Tampa Bay Devil Rays 7pm MELISSA WIN 9-1 WP: C.Schilling |
| | 20 | vs. Tampa Bay Devil Rays 7pm TOM loss 1-5 |
| | 21 | away at Toronto Blue Jays 7pm loss 6-7 (12th) |
| | 22 | away at Toronto Blue Jays 1pm loss 1-8 |
|
| 23 | away at Toronto Blue Jays 1pm WIN 6-3 WP: M.Clement |
| | | 25 | away at Cleveland Indians 7pm WIN 8-6 WP: K.Foulke |
| | 26 | away at Cleveland Indians 7pm loss 1-7 |
| | 27 | away at Cleveland Indians 7pm loss 3-15 |
| | 28 | away at Tampa Bay Devil Rays 7pm loss 2-5 |
| | 29 | away at Tampa Bay Devil Rays 7pm WIN 9-6 WP: K.Foulke |
|
| 30 | away at Tampa Bay Devil Rays 1pm loss 4-5 |
|
| Sun | Mon | Tue | Wed | Thu | Fri | Sat |
| | 1 | vs. New York Yankees 7pm JON WIN 7-3 WP: M.Timlin |
| | 2 | vs. New York Yankees 7pm ROB |
| | 3 | vs. Toronto Blue Jays 7pm RAE loss 6-7 |
| | 4 | vs. Toronto Blue Jays 7pm PAUL WIN 7-4 WP: M.Clement |
| | 5 | vs. Baltimore Orioles 7pm RON WIN 6-3 WP: C.Schilling |
| | 6 | vs. Baltimore Orioles 7pm JON WIN 9-3 WP: T.Wakefield |
|
| 7 | vs. Baltimore Orioles 2pm SETH WIN 10-3 WP: L.DiNardo |
| | | 9 | away at New York Yankees 7pm WIN 14-3 WP: J.Beckett |
| | 10 | away at New York Yankees 7pm loss 3-7 |
| | 11 | away at New York Yankees 7pm WIN 5-3 WP: T.Wakefield |
| | 12 | vs. Texas Rangers 7pm ADAM K loss 0-6 (6th) |
| | 13 | vs. Texas Rangers 7pm ROB |
|
| 14 | vs. Texas Rangers 2pm JON |
| | 15 | away at Baltimore Orioles 7pm WIN 11-1 WP: J.Beckett |
| | 16 | away at Baltimore Orioles 7pm WIN 6-5 WP: C.Schilling |
| | 17 | away at Baltimore Orioles 7pm loss 3-4 |
| | | 19 | away at Philadelphia Phillies 7pm WIN 5-3 WP: M.Clement |
| | 20 | away at Philadelphia Phillies 7pm WIN 8-4 WP: J.Beckett |
|
| 21 | away at Philadelphia Phillies 1pm loss 5-10 |
| | 22 | vs. New York Yankees 7pm SETH WIN 9-5 WP: C.Schilling |
| | 23 | vs. New York Yankees 7pm RON loss 5-7 |
| | 24 | vs. New York Yankees 7pm JON loss 6-8 |
| | 25 | vs. Tampa Bay Devil Rays 7pm RAE WIN 4-1 WP: J.Beckett |
| | 26 | vs. Tampa Bay Devil Rays 7pm RON WIN 8-4 WP: J.Tavarez |
| | 27 | vs. Tampa Bay Devil Rays 7pm PAUL WIN 6-4 WP: C.Schilling |
|
| 28 | vs. Tampa Bay Devil Rays 2pm JON WIN 5-4 WP: T.Wakefield |
| | 29 | away at Toronto Blue Jays 7pm loss 6-7 |
| | 30 | away at Toronto Blue Jays 7pm loss 5-8 |
| | 31 | away at Toronto Blue Jays 7pm WIN 8-6 WP: J.Van Buren |
|
| Sun | Mon | Tue | Wed | Thu | Fri | Sat |
| | | | | | 2 | away at Detroit Tigers 7pm WIN 3-2 WP: R.Seanez |
| | 3 | away at Detroit Tigers 7pm loss 2-6 |
|
| 4 | away at Detroit Tigers 1pm WIN 8-3 WP: M.Clement |
| | 5 | away at New York Yankees 7pm loss 5-13 |
| | 6 | away at New York Yankees 7pm loss 1-2 |
| | 7 | away at New York Yankees 7pm |
| | 8 | away at New York Yankees 7pm WIN 9-3 WP: C.Schilling |
| | 9 | vs. Texas Rangers 7pm JON WIN 4-3 WP: J.Papelbon |
| | 10 | vs. Texas Rangers 7pm PAUL loss 4-7 |
|
| 11 | vs. Texas Rangers 2pm SETH loss 6-13 |
| | | 13 | away at Minnesota Twins 8pm loss 2-5 (12th) |
| | 14 | away at Minnesota Twins 8pm loss 1-8 |
| | 15 | away at Minnesota Twins 8pm loss 3-5 |
| | 16 | away at Atlanta Braves 7pm WIN 4-1 WP: J.Lester |
| | 17 | away at Atlanta Braves 1pm (FOX) WIN 5-3 WP: J.Beckett |
|
| 18 | away at Atlanta Braves 1pm WIN 10-7 WP: R.Seanez |
| | 19 | vs. Washington Nationals 7pm PAUL WIN 6-3 WP: K.Snyder |
| | 20 | vs. Washington Nationals 7pm RAE WIN 11-3 WP: T.Wakefield |
| | 21 | vs. Washington Nationals 7pm JON WIN 9-3 WP: J.Lester |
| | | 23 | vs. Philadelphia Phillies 7pm RON WIN 10-2 WP: J.Beckett |
| | 24 | vs. Philadelphia Phillies 1pm (FOX) ROB WIN 5-3 (10th) WP: J.Papelbon |
|
| 25 | vs. Philadelphia Phillies 2pm JON |
| | | 27 | vs. New York Mets 7pm SETH WIN 9-4 WP: J.Lester |
| | 28 | vs. New York Mets 7pm RAE WIN 10-2 WP: J.Beckett |
| | 29 | vs. New York Mets 7pm JON WIN 4-2 WP: C.Schilling |
| | 30 | away at Florida Marlins 7pm loss 2-5 |
|
| Sun | Mon | Tue | Wed | Thu | Fri | Sat |
| | | | | | | 1 | away at Florida Marlins 6pm WIN 11-5 WP: T.Wakefield |
|
| 2 | away at Florida Marlins 1pm WIN 4-3 WP: M.Timlin |
| | 3 | away at Tampa Bay Devil Rays 7pm loss 0-3 |
| | 4 | away at Tampa Bay Devil Rays 4pm loss 6-9 |
| | 5 | away at Tampa Bay Devil Rays 7pm loss 2-5 |
| | 6 | away at Tampa Bay Devil Rays 7pm WIN 12-5 WP: T.Wakefield |
| | 7 | away at Chicago White Sox 8pm WIN 7-2 WP: J.Lester |
| | 8 | away at Chicago White Sox 1pm (FOX) WIN 9-6 WP: J.Beckett |
|
| 9 | away at Chicago White Sox 2pm loss 5-6 (19th) |
| | | | | 13 | vs. Oakland Athletics 7pm CHRIS loss 4-5 (11th) |
| | 14 | vs. Oakland Athletics 7pm RON loss 3-15 |
| | 15 | vs. Oakland Athletics 7pm SETH WIN 7-0 WP: C.Schilling |
|
| 16 | vs. Oakland Athletics 2pm JON loss 1-8 |
| | 17 | vs. Kansas City Royals 7pm ROB WIN 5-4 WP: M.Timlin |
| | 18 | vs. Kansas City Royals 7pm RAE WIN 1-0 WP: J.Lester |
| | 19 | vs. Kansas City Royals 1pm PAUL WIN 1-0 WP: J.Beckett |
| | | 21 | away at Seattle Mariners 10pm WIN 9-4 WP: K.Snyder |
| | 22 | away at Seattle Mariners 4pm loss 2-5 |
|
| 23 | away at Seattle Mariners 4pm loss 8-9 |
| | 24 | away at Oakland Athletics 10pm WIN 7-3 WP: J.Beckett |
| | 25 | away at Oakland Athletics 10pm WIN 13-5 WP: C.Schilling |
| | 26 | away at Oakland Athletics 3pm loss 1-5 |
| | | 28 | vs. Anaheim Angels 7pm ADAM K loss 3-8 |
| | 29 | vs. Anaheim Angels 1pm (FOX) ROB WIN 7-6 (11th) WP: J.Tavarez |
|
| 30 | vs. Anaheim Angels 2pm JON loss 4-10 |
| | 31 | vs. Cleveland Indians 7pm TOM WIN 9-8 WP: K.Snyder |
|
| Sun | Mon | Tue | Wed | Thu | Fri | Sat |
| | | 1 | vs. Cleveland Indians 7pm RAE loss 3-6 |
| | 2 | vs. Cleveland Indians 7pm PAUL WIN 6-5 WP: J.Papelbon |
| | 3 | vs. Cleveland Indians 7pm JON loss 6-7 |
| | 4 | away at Tampa Bay Devil Rays 7pm WIN 3-2 WP: C.Schilling |
| | 5 | away at Tampa Bay Devil Rays 7pm loss 5-8 |
|
| 6 | away at Tampa Bay Devil Rays 1pm loss 6-7 (10th) |
| | | 8 | away at Kansas City Royals 8pm loss 4-6 |
| | 9 | away at Kansas City Royals 8pm loss 4-5 |
| | 10 | away at Kansas City Royals 8pm loss 4-5 |
| | 11 | vs. Baltimore Orioles 7pm CHRIS WIN 9-2 WP: D.Wells |
| | 12 | vs. Baltimore Orioles 1pm (FOX) RON WIN 8-7 (10th) WP: J.Papelbon |
|
| 13 | vs. Baltimore Orioles 2pm JON WIN 11-9 WP: J.Lester |
| | 14 | vs. Detroit Tigers 7pm SETH loss 4-7 |
| | 15 | vs. Detroit Tigers 7pm ROB loss 2-3 |
| | 16 | vs. Detroit Tigers 7pm TOM WIN 6-4 WP: D.Wells |
| | | 18 | vs. New York Yankees 8pm JON loss 11-14 |
| | 19 | vs. New York Yankees 1pm (FOX) RAE loss 5-13 |
|
| 20 | vs. New York Yankees 8pm (ESPN) PAUL loss 5-8 (10th) |
| | 21 | vs. New York Yankees 1pm JON loss 1-2 |
| | 22 | away at Anaheim Angels 10pm loss 3-4 |
| | 23 | away at Anaheim Angels 10pm WIN 5-4 WP: J.Lester |
| | 24 | away at Anaheim Angels 10pm WIN 2-1 WP: J.Beckett |
| | 25 | away at Seattle Mariners 10pm loss 0-6 |
| | 26 | away at Seattle Mariners 10pm loss 3-4 |
|
| 27 | away at Seattle Mariners 4pm loss 3-6 |
| | 28 | away at Oakland Athletics 10pm loss 0-9 |
| | 29 | away at Oakland Athletics 10pm loss 1-2 |
| | 30 | away at Oakland Athletics 3pm loss 2-7 |
| | 31 | vs. Toronto Blue Jays 7pm CHRIS WIN 6-4 WP: M.Delcarmen |
|
| Sun | Mon | Tue | Wed | Thu | Fri | Sat |
| | | | | | 1 | vs. Toronto Blue Jays 7pm ADAM K WIN 2-1 WP: K.Snyder |
| | 2 | vs. Toronto Blue Jays 1pm JON loss 1-5 |
|
| 3 | vs. Toronto Blue Jays 4pm PAUL loss 1-6 |
| | 4 | vs. Chicago White Sox 7pm (Labor Day) JON WIN 3-2 (10th) WP: M.Timlin |
| | 5 | vs. Chicago White Sox 7pm SETH WIN 1-0 WP: K.Gabbard |
| | 6 | vs. Chicago White Sox 7pm ROB loss 1-8 |
| | | 8 | vs. Kansas City Royals 7pm ADAM K loss 9-10 |
| | 9 | vs. Kansas City Royals 7pm RON loss 4-10 (12th) |
|
| 10 | vs. Kansas City Royals 2pm JON WIN 9-3 WP: J.Tavarez |
| | | 12 | away at Baltimore Orioles 7pm WIN 6-5 WP: C.Hansen |
| | 13 | away at Baltimore Orioles 7pm loss 0-4 |
| | 14 | away at Baltimore Orioles 7pm WIN 6-5 WP: K.Foulke |
| | 15 | away at New York Yankees 7pm |
| | 16 | away at New York Yankees 1pm (FOX) loss 5-7 |
|
| 17 | away at New York Yankees 1pm WIN 5-4 WP: J.Lopez |
| | | 19 | vs. Minnesota Twins 7pm JON loss 3-7 |
| | 20 | vs. Minnesota Twins 7pm TOM loss 2-8 |
| | 21 | vs. Minnesota Twins 7pm RON WIN 6-0 WP: J.Beckett |
| | 22 | away at Toronto Blue Jays 7pm WIN 7-1 WP: J.Tavarez |
| | 23 | away at Toronto Blue Jays 4pm loss 3-5 |
|
| 24 | away at Toronto Blue Jays 1pm loss 4-13 |
| | 25 | away at Toronto Blue Jays 7pm loss 0-5 |
| | 26 | vs. Tampa Bay Devil Rays 7pm RAE WIN 5-1 WP: C.Schilling |
| | 27 | vs. Tampa Bay Devil Rays 7pm JON loss 0-11 |
| | | 29 | vs. Baltimore Orioles 7pm SETH WIN 4-3 WP: J.Tavarez |
| | 30 | vs. Baltimore Orioles 7pm PAUL loss 4-5 |
|